Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP*

The endoplasmic reticulum membrane protein SREBP cleavage-activating protein (Scap) senses sterols and regulates activation of sterol-regulatory element binding proteins (SREBPs), membrane-bound transcription factors that control lipid homeostasis in fission yeast and mammals. Transmembrane segments...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Adam L. Hughes, Emerson V. Stewart, Peter J. Espenshade
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2008-09-01
Schriftenreihe:	Journal of Lipid Research
Schlagworte:	sterol-regulatory element binding protein cholesterol SREBP cleavage-activating protein sterol oxygen Sre1
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S002222752034668X
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