Selection of Shared and Neoantigen-Reactive T Cells for Adoptive Cell Therapy Based on CD137 Separation

Adoptive cell therapy (ACT) of autologous tumor infiltrating lymphocytes (TIL) is an effective immunotherapy for patients with solid tumors, yielding objective response rates of around 40% in refractory patients with metastatic melanoma. Most clinical centers utilize bulk, randomly isolated TIL from...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Sivan Seliktar-Ofir, Efrat Merhavi-Shoham, Orit Itzhaki, Sharon Yunger, Gal Markel, Jacob Schachter, Michal J. Besser
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Frontiers Media S.A. 2017-10-01
Sarja:	Frontiers in Immunology
Aiheet:	adoptive cell therapy melanoma tumor infiltrating lymphocytes (TIL) CD137 neoantigen tumor antigen
Linkit:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.01211/full
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