Improving Transungual Permeation Study Design by Increased Bovine Hoof Membrane Thickness and Subsequent Infection

Ungual formulations are regularly tested using human nails or animal surrogates in Franz diffusion cell experiments. Membranes sometimes less than 100 µm thick are used, disregarding the higher physiological thickness of human nails and possible fungal infection. In this study, bovine hoof membranes...

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Autori principali:	Sebastian Kappes, Thilo Faber, Lotta Nelleßen, Tanju Yesilkaya, Udo Bock, Alf Lamprecht
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2021-12-01
Serie:	Pharmaceutics
Soggetti:	ungual permeation model onychomycosis bovine hoof bifonazole scanning electron microscopy
Accesso online:	https://www.mdpi.com/1999-4923/13/12/2098
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