E3 Ubiquitin ligases Cbl-b and c-Cbl maintain the homeostasis of macrophages by regulating the M-CSF/M-CSFR signaling axis

Abstract The Casitas B-lineage lymphoma (Cbl) family proteins are E3 ubiquitin ligases implicated in the regulation of various immune cells. However, their function in macrophages remains unclear. Here, we identify both Cbl-b and c-Cbl (Cbls) as inhibitors of macrophage proliferation and promoters o...

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Autori principali:	Fei Xu, Chensheng Tan, Kun Tang, Guodong Qiao, Yu Shao, Xiaoping Li, Ji Zhou, Peijie Zhu, Mengyun Wu, Jiamin Cai, Xiu Gao, Yufeng Wang, Beibei Huang, Wenjun Wang, Tian Xia, Xuena Xu, Jiaoyang Li, Zhengrong Chen, Yufang Shi, Chuangli Hao, Yi Yang, Jinping Zhang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2025-10-01
Serie:	Cell Death and Disease
Accesso online:	https://doi.org/10.1038/s41419-025-08047-4
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