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Gene Delivery of Manf to Beta-Cells of the Pancreatic Islets Protects NOD Mice from Type 1 Diabetes Development

In type 1 diabetes, dysfunctional glucose regulation occurs due to the death of insulin-producing beta-cells in the pancreatic islets. Initiation of this process is caused by the inheritance of an adaptive immune system that is predisposed to responding to beta-cell antigens, most notably to insulin...

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Principais autores: Kailash Singh, Orian Bricard, Jeason Haughton, Mikaela Björkqvist, Moa Thorstensson, Zhengkang Luo, Loriana Mascali, Emanuela Pasciuto, Chantal Mathieu, James Dooley, Adrian Liston
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-10-01
Serier:Biomolecules
Fag:
type 1 diabetes
AAV
Manf
gene delivery
NOD mice
beta-cells
Online adgang:https://www.mdpi.com/2218-273X/12/10/1493
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