The Reaction Specificity of Mammalian ALOX15 Orthologs is Changed During Late Primate Evolution and These Alterations Might Offer Evolutionary Advantages for Hominidae

Arachidonic acid lipoxygenases (ALOXs) have been implicated in the immune response of mammals. The reaction specificity of these enzymes is decisive for their biological functions and ALOX classification is based on this enzyme property. Comparing the amino acid sequences and the functional properti...

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Hlavní autoři:	Dagmar Heydeck, Florian Reisch, Marjann Schäfer, Kumar R. Kakularam, Sophie A. Roigas, Sabine Stehling, Gerhard P. Püschel, Hartmut Kuhn
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-04-01
Edice:	Frontiers in Cell and Developmental Biology
Témata:	eicosanoids lipid peroxidation oxidative stress recombinant proteins ferroptosis
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fcell.2022.871585/full
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