Clonal heterogeneity in ER+ breast cancer reveals the proteasome and PKC as potential therapeutic targets

Abstract Intratumoral heterogeneity impacts the success or failure of anti-cancer therapies. Here, we investigated the evolution and mechanistic heterogeneity in clonal populations of cell models for estrogen receptor positive breast cancer. To this end, we established barcoded models of luminal bre...

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Hlavní autoři:	Lukas Beumers, Efstathios-Iason Vlachavas, Simone Borgoni, Luisa Schwarzmüller, Luca Penso-Dolfin, Birgitta E. Michels, Emre Sofyali, Sara Burmester, Daniela Heiss, Heike Wilhelm, Yosef Yarden, Dominic Helm, Rainer Will, Angela Goncalves, Stefan Wiemann
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2023-12-01
Edice:	npj Breast Cancer
On-line přístup:	https://doi.org/10.1038/s41523-023-00604-4
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