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CTP promotes efficient ParB-dependent DNA condensation by facilitating one-dimensional diffusion from parS

Faithful segregation of bacterial chromosomes relies on the ParABS partitioning system and the SMC complex. In this work, we used single-molecule techniques to investigate the role of cytidine triphosphate (CTP) binding and hydrolysis in the critical interaction between centromere-like parS DNA sequ...

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Principais autores: Francisco de Asis Balaguer, Clara Aicart-Ramos, Gemma LM Fisher, Sara de Bragança, Eva M Martin-Cuevas, Cesar L Pastrana, Mark Simon Dillingham, Fernando Moreno-Herrero
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2021-07-01
Serier:eLife
Fag:
ParB
ParABS systems
chromosome segregation
magnetic tweezers
single-molecule techniques
optical tweezers
Online adgang:https://elifesciences.org/articles/67554
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