Janus kinase inhibitors in systemic lupus erythematosus: implications for tyrosine kinase 2 inhibition

Aberrant activation of the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway is common in systemic lupus erythematosus (SLE), conferring immune-mediated properties in target tissues. Multiple cytokines activate different combinations of JAKs and STATs to alter th...

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Bibliografische Detailangaben

Hauptverfasser:	Dionysis Nikolopoulos, Ioannis Parodis
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2023-06-01
Schriftenreihe:	Frontiers in Medicine
Schlagworte:	systemic lupus erythematosus JAK inhibitors TYK2 treatment small molecules
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fmed.2023.1217147/full
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