15-Lipoxygenase-1 Expression Upregulates and Activates Insulin-Like Growth Factor-1 Receptor in Prostate Cancer Cells

We previously discovered that a fat-metabolizing enzyme, 15-lipoxygenase-1 (15-LO-1), is high in human prostate cancer (PCa) and correlates with disease progression. The biologic link between the aberrant 15-LO-1/linoleic acid (LA) metabolism and fat (which is a rich source of growth factors) in PCa...

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Principais autores:	Uddhav P. Kelavkar, Cynthia Cohen
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2004-01-01
סדרה:	Neoplasia: An International Journal for Oncology Research
נושאים:	15-lipoxygenase-1 (15-LO-1) hydroxyoctadecadienoic acid (NODE) insulinlike growth factor-1 (IGF-1) insulin-like growth factor-1 receptor (IGF-1R) linoleic acid (LA)
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S1476558604800526
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