Synthesis, Antimycobacterial Activity and In Vitro Cytotoxicity of 5-Chloro-N-phenylpyrazine-2-carboxamides

5-Chloropyrazinamide (5-Cl-PZA) is an inhibitor of mycobacterial fatty acid synthase I with a broad spectrum of antimycobacterial activity in vitro. Some N-phenylpyrazine-2-carboxamides with different substituents on both the pyrazine and phenyl core possess significant in vitro activity against My...

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Huvudupphov:	Jan Zitko, Barbora Servusová, Pavla Paterová, Jana Mandíková, Vladimír Kubíček, Radim Kučera, Veronika Hrabcová, Jiří Kuneš, Ondřej Soukup, Martin Doležal
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	MDPI AG 2013-12-01
Serie:	Molecules
Ämnen:	pyrazinamide 5-chloropyrazinamide anilides antimycobacterial activity cytotoxicity
Länkar:	http://www.mdpi.com/1420-3049/18/12/14807
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