Doxorubicin-Loaded Polymeric Micelles Conjugated with CKR- and EVQ-FLT3 Peptides for Cytotoxicity in Leukemic Stem Cells

Doxorubicin (Dox) is the standard chemotherapeutic agent for acute myeloblastic leukemia (AML) treatment. However, 40% of Dox-treated AML cases relapsed due to the presence of leukemic stem cells (LSCs). Thus, poloxamer 407 and CKR- and EVQ-FLT3 peptides were used to formulate Dox-micelles (DMs) and...

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Principais autores:	Fah Chueahongthong, Singkome Tima, Sawitree Chiampanichayakul, Pornngarm Dejkriengkraikul, Siriporn Okonogi, Mathurada Sasarom, Soraya Rodwattanagul, Cory Berkland, Songyot Anuchapreeda
格式:	Artigo
語言:	Inglês
出版:	MDPI AG 2022-10-01
叢編:	Pharmaceutics
主題:	doxorubicin CKR EVQ polymeric micelle leukemic stem cell co-treatment
在線閱讀:	https://www.mdpi.com/1999-4923/14/10/2115
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