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The clinical utility and safety of biomarker-guided immunosuppression withdrawal in liver transplantation: the LIFT prospective RCT

Background Long-term surviving liver transplant recipients can spontaneously develop operational tolerance, which allows them to completely discontinue their immunosuppression, but we lack validated tools to predict the likelihood of rejection following immunosuppression withdrawal. A previous clini...

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Principais autores: Julien Vionnet, Rosa Miquel, Juan G Abraldes, Juan-Jose Lozano, Pablo Ruiz, Miquel Navasa, Aileen Marshall, Frederik Nevens, William Gelson, Joanna Leithead, Steven Masson, Elmar Jaeckel, Richard Taubert, Phaedra Tachtatzis, Dennis Eurich, Kenneth Simpson, Eliano Bonaccorsi-Riani, James Ferguson, Alberto Quaglia, Maria Elstad, Marc Delord, Abdel Douiri, Alberto Sánchez-Fueyo
Formato: Artigo
Idioma:Inglês
Publicado em: NIHR Journals Library 2025-04-01
coleção:Efficacy and Mechanism Evaluation
Assuntos:
humans
adult
middle aged
liver transplantation
prospective studies
arm
berlin
cause of death
control groups
elasticity imaging techniques
incidence
london
prevalence
weaning
neoplasms
immunosuppression therapy
liver
biomarkers
outcome assessment
health care
transaminases
allografts
biopsy
randomised controlled trials as topic
multicentre studies as topic
clinical trials
phase iv as topic
Acesso em linha:https://doi.org/10.3310/FWXV5380
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