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Succinate mediates inflammation-induced adrenocortical dysfunction

The hypothalamus-pituitary-adrenal (HPA) axis is activated in response to inflammation leading to increased production of anti-inflammatory glucocorticoids by the adrenal cortex, thereby representing an endogenous feedback loop. However, severe inflammation reduces the responsiveness of the adrenal...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Ivona Mateska, Anke Witt, Eman Hagag, Anupam Sinha, Canelif Yilmaz, Evangelia Thanou, Na Sun, Ourania Kolliniati, Maria Patschin, Heba Abdelmegeed, Holger Henneicke, Waldemar Kanczkowski, Ben Wielockx, Christos Tsatsanis, Andreas Dahl, Axel Karl Walch, Ka Wan Li, Mirko Peitzsch, Triantafyllos Chavakis, Vasileia Ismini Alexaki
Hōputu: Artigo
Reo:Inglês
I whakaputaina: eLife Sciences Publications Ltd 2023-07-01
Rangatū:eLife
Ngā marau:
adrenal gland
succinate dehydrogenase
succinate
glucocorticoids
IL-1β
DNMT1
Urunga tuihono:https://elifesciences.org/articles/83064
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