Limosilactobacillus reuteri alleviates proinflammatory T-cell-mediated liver injury and transcriptomic changes in immunocompromised mice

BackgroundA deficiency of immunosuppressive regulatory T cells, as seen in scurfy (SF) mice or in IPEX syndrome in humans, can lead to multiorgan inflammation. Oral administration of the probiotic Limosilactobacillus reuteri Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM) 17938 pro...

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Principais autores:	Ana Fadhel Alvarez, Zheng Yin, Beanna Okeugo, Alexander Banerjee, Meng Luo, Christopher M. Taylor, Salomea Giorgberidze, Vaishali Harne, Rambabu Majji, Melissa N. Munroe, Ji Ho Suh, Stephen T. C. Wong, Kang Ho Kim, Hari Krishna Yalamanchili, Suhair Al Salihi, Jon Marc Rhoads, Yuying Liu
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2026-03-01
Series:	Frontiers in Immunology
Assuntos:	autoimmunity gut microbiota hepatic transcriptome inflammation probiotic-modulated T cell probiotics
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1713120/full
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