Dimeric PKM2 in chondrocytes impairs mitochondrial homeostasis in osteoarthritis
Abstract Cartilage degradation is considered a hallmark of end-stage osteoarthritis (OA), characterized by significant alterations in the extracellular matrix (ECM). This study examines the role of pyruvate kinase muscle type 2 (PKM2) dimerization in cartilage degradation and ECM homeostasis in OA....
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2026-03-01
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| Series: | Cell Death and Disease |
| Acceso en liña: | https://doi.org/10.1038/s41419-026-08621-4 |
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