Epigenomic study of the lower airway reveals COPD-associated methylation patterns and potential microbiota links

Introduction Despite the identification of multiple susceptibility loci by genome-wide association studies (GWAS), considerable chronic obstructive pulmonary disease (COPD) heritability remains unexplained.Aim To identify interaction networks of airway epithelial cell DNA methylation in COPD and fur...

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Bibliografski detalji

Glavni autori:	Siddharth Madapoosi, Yvonne Jean Huang, Christopher B Cooper, Russell Bowler, Victor Kim, Fernando J Martinez, David Couper, Benjamin Smith, Stephanie Christenson, Nadia N Hansel, Victor E Ortega, Jeffrey L Curtis, Xianfeng Chen, Prescott G Woodruff, Alejandro Comellas, Eric A Hoffman, Eugene R Bleecker, Richard E Kanner, Wanda K O’Neal, Wendy C Moore, John Erb-Downward, MeiLan Han, Robert Kaner, Robert Paine, Timothy D Howard, Deborah A Meyers, Annette T Hastie, Gregory A Hawkins, Shuo Cao, Abhishek Shrivastav, Joe Zein, Igor Z Barjaktarevic, Robert Graham Barr
Format:	Artigo
Jezik:	Inglês
Izdano:	BMJ Publishing Group 2025-12-01
Serija:	BMJ Open Respiratory Research
Online pristup:	https://bmjopenrespres.bmj.com/content/12/1/e003572.full
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