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NK Cell-Mediated Eradication of Ovarian Cancer Cells with a Novel Chimeric Antigen Receptor Directed against CD44

Ovarian cancer is the most common cause of gynecological cancer-related death in the developed world. Disease recurrence and chemoresistance are major causes of poor survival rates in ovarian cancer patients. Ovarian cancer stem cells (CSCs) were shown to represent a source of tumor recurrence owing...

Celý popis

Uloženo v:
Hlavní autoři: Rüdiger Klapdor, Shuo Wang, Michael A. Morgan, Katharina Zimmermann, Jens Hachenberg, Hildegard Büning, Thilo Dörk, Peter Hillemanns, Axel Schambach
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2021-09-01
Edice:Biomedicines
Témata:
chimeric antigen receptor
ovarian cancer
CD44
adoptive immunotherapy
NK cells
On-line přístup:https://www.mdpi.com/2227-9059/9/10/1339
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