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CAR T Cells: A Snapshot on the Growing Options to Design a CAR

Abstract. Adoptive cell therapy of malignant diseases with chimeric antigen receptor (CAR) modified T cells rapidly advanced from pre-clinical models to commercial approvals within 2 decades. CARs redirect patient's T cells towards cancer cells and activate the engineered cells for a cytolytic attac...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Hauptverfasser: Astrid Holzinger, Hinrich Abken
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wiley 2019-02-01
Schriftenreihe:HemaSphere
Online-Zugang:http://journals.lww.com/10.1097/HS9.0000000000000172
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