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Calpain-mediated proteolysis as driver and modulator of polyglutamine toxicity

Among posttranslational modifications, directed proteolytic processes have the strongest impact on protein integrity. They are executed by a variety of cellular machineries and lead to a wide range of molecular consequences. Compared to other forms of proteolytic enzymes, the class of calcium-activa...

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Principais autores: Rana Dilara Incebacak Eltemur, Huu Phuc Nguyen, Jonasz Jeremiasz Weber
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-10-01
coleção:Frontiers in Molecular Neuroscience
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Acesso em linha:https://www.frontiersin.org/articles/10.3389/fnmol.2022.1020104/full
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