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[13C]bicarbonate labelled from hyperpolarized [1-13C]pyruvate is an in vivo marker of hepatic gluconeogenesis in fasted state

Can et al. demonstrate the ability to use hyperpolarized [1-13C]pyruvate at nearphysiological concentrations to directly assess liver enzymatic activities by 13C magnetic resonance. While in the fed state, the normalized [13C]bicarbonate signal produced from hyperpolarized [1-13C]pyruvate derives fr...

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Bibliografiska uppgifter
Huvudupphov: Emine Can, Jessica A. M. Bastiaansen, Dominique-Laurent Couturier, Rolf Gruetter, Hikari A. I. Yoshihara, Arnaud Comment
Materialtyp: Artigo
Språk:Inglês
Utgiven: Nature Portfolio 2022-01-01
Serie:Communications Biology
Länkar:https://doi.org/10.1038/s42003-021-02978-2
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