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LASS2 suppresses metastasis in multiple cancers by regulating the ferroptosis signalling pathway through interaction with TFRC

Abstract Background As a key enzyme in ceramide synthesis, longevity assurance homologue 2 (LASS2) has been indicated to act as a tumour suppressor in a variety of cancers. Ferroptosis is involved in a variety of tumour processes; however, the role of LASS2 in regulating ferroptosis has yet to be ex...

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Principais autores: Yunfei Huang, Jie Du, Dan Li, Wei He, Zhouheng Liu, Li Liu, Xiaoli Yang, Xiaoming Cheng, Rui Chen, Yan Yang
Format: Artigo
Jezik:Inglês
Izdano: BMC 2024-02-01
Serija:Cancer Cell International
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Online dostop:https://doi.org/10.1186/s12935-024-03275-8
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