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Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Abstract Essential thrombocythemia (ET) includes the JAK2 ‐, CALR‐, and MPL‐mutated subtypes, and a triple‐negative (TN) ET subtype, which lacks these canonical drivers. How specific driver mutations affect hematopoietic stem cell (HSC) heterogeneity and their relation to ET pathogenesis remain uncl...

Deskribapen osoa

Gorde:
Egile Nagusiak: Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Wiley 2026-02-01
Saila:Advanced Science
Gaiak:
CALR
CXCR4
essential thrombocythemia (ET)
MPL
myeloproliferative neoplasms (MPN)
scRNA‐seq
Sarrera elektronikoa:https://doi.org/10.1002/advs.202505249
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