Cefotaxime Exposure Selects Mutations within the CA-Domain of envZ Which Promote Antibiotic Resistance but Repress Biofilm Formation in Salmonella

ABSTRACT Cephalosporins are important beta lactam antibiotics, but resistance can be mediated by various mechanisms including production of beta lactamase enzymes, changes in membrane permeability or active efflux. We used an evolution model to study how Salmonella adapts to subinhibitory concentrat...

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Hlavní autoři:	Eleftheria Trampari, Chuanzhen Zhang, Kathryn Gotts, George M. Savva, Vassiliy N. Bavro, Mark Webber
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2022-06-01
Edice:	Microbiology Spectrum
Témata:	antimicrobial resistance biofilms evolution two component systems
On-line přístup:	https://journals.asm.org/doi/10.1128/spectrum.02145-21
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