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Unveiling the role of acetate in probiotic-mediated promotion of intestinal serotonin production using intestinal organoids

The neurotransmitter 5-hydroxytryptamine (5-HT), primarily produced by intestinal enterochromaffin (EC) cells, relies on tryptophan hydroxylase 1 (TPH1) for synthesis. Research suggested Bifidobacterium breve CCFM1025’s potential in regulating Tph1 gene expression, maintaining 5-HT levels in stresse...

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Principais autores: Peijun Tian, Zheng Wang, Xin Qian, Jianxin Zhao, Gang Wang, Wei Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Tsinghua University Press 2025-08-01
coleção:Food Science and Human Wellness
Assuntos:
5-hydroxytryptamine
bifidobacterium
acetate
organoids
tryptophan hydroxylase
Acesso em linha:https://www.sciopen.com/article/10.26599/FSHW.2024.9250314
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