Aberrant N-glycosylation may be a therapeutic target in carriers of a common and highly pleiotropic variant in the manganese transporter ZIP8

Summary: The treatment of defective glycosylation in clinical practice has been limited to patients with rare and severe phenotypes associated with congenital disorders of glycosylation (CDGs). Carried by approximately 5% of the human population, the discovery of the highly pleiotropic, missense var...

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Detalhes bibliográficos

Principais autores:	Vartika Tomar, John Kang, Ruxian Lin, Steven R. Brant, Mark Lazarev, Caitlin Tressler, Kristine Glunde, Natasha Zachara, Joanna Melia
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-01-01
Colecção:	HGG Advances
Assuntos:	ZIP8 SLC39A8 N-glycosylation manganese Crohn disease N-acetylglucosamine
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2666247725001204
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