Long-acting β2 agonist (LABA) with a long-acting muscarinic receptor antagonist (LAMA) promotes human airway smooth muscle (HASM) relaxation and circumvents β2 adrenergic receptor tachyphylaxis

Abstract To fill the gap in the knowledge between clinical studies and pre-clinical mechanistic studies using combined LABA/LAMA therapy, we hypothesized that the combination is more effective in attenuating excitation-contraction (E-C) coupling compared to either LAMA or LABA alone in human airway...

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Bibliografische Detailangaben

Hauptverfasser:	Joseph Jude, Nikhil Karmacharya, Rinzhin T. Sherpa, Thomas G. O’Riordan, Cynthia J. Koziol-White, Reynold A. Jr. Panettieri
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-12-01
Schriftenreihe:	Respiratory Research
Schlagworte:	Asthma Chronic obstructive lung disease β2 agonist tolerance Bronchodilation Bronchoconstriction Persistent airflow obstruction
Online-Zugang:	https://doi.org/10.1186/s12931-025-03427-y
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