IRF2 deficiency disrupts pyroptosis, NK cell interferon-γ production and resistance to Francisella

Abstract IRF2 plays an indirect role in inflammasome activation by regulating Caspase-4 and Gasdermin D (GSDMD) levels. However, the in vivo relevance of this regulatory circuit is unknown. We generate IRF2KO mice and demonstrate that they are equally susceptible to Francisella novicida infection as...

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Autori principali:	Maxence Cornut, Sophia Djebali, Elena Rondeau, Sarah Dayet, Théo Fayolle, Julie Haagen, Lucie Fallone, Noémi Rousseaux, Emmanuelle Caspar, Mélissa Marcotte, Amandine Martin, Elise Courteboeuf, Maëlan Deschamps-Biboulet, Marie Teixeira, Jacqueline Marvel, Bénédicte F Py, Thierry Walzer, Antoine Marcais, Thomas Henry, Émilie Bourdonnay
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer Nature 2026-01-01
Serie:	EMBO Reports
Soggetti:	IRF2 Gasdermin D NK Cells IFN- γ Francisella novicida
Accesso online:	https://doi.org/10.1038/s44319-026-00698-4
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