Meningeal lymphatic dysfunction mediates postoperative sleep deprivation-induced cognitive decline via impaired neuroinflammatory clearance

Abstract Postoperative sleep deprivation (PSD) exacerbates perioperative neurocognitive disorders (PND) through unresolved neuroinflammation, yet the underlying mechanisms remain elusive. Here, we aim to evaluate contribution of disregulation of the meningeal lymphatic vessels (MLVs) to PSD-induced...

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Hlavní autoři:	Binkang Huang, Wei Tu, Han Zhou, Lan Mo, Qiubo Yang, Yilong Sheng, Daofan Sun, Bo Meng, Zhexi Chi, Yingying Lv, Rongjun Liu, Xiuzhong Xing, Hui Yuan, Jing Yang, Fengdeng Hu, Guo Chen, Junping Chen, Xiaowei Chen, Bo Lu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-03-01
Edice:	Journal of Neuroinflammation
Témata:	Meningeal lymphatics Sleep deprivation Neuroinflammation Perioperative neurocognitive disorders VEGF-C
On-line přístup:	https://doi.org/10.1186/s12974-026-03784-5
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