Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis

Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) target a wide range of modified proteins. Citrullination occurs during physiological processes such as apoptosis, yet little is known about the interaction of ACPA with nuclear antigens or apoptotic cells. Since un...

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Bibliografische gegevens

Hoofdauteurs:	Katy A. Lloyd, Gustaf Wigerblad, Peter Sahlström, Manasa G. Garimella, Karine Chemin, Johanna Steen, Philip J. Titcombe, Bianka Marklein, Diana Zhou, Ragnhild Stålesen, Elena Ossipova, Christina Lundqvist, Olov Ekwall, Johan Rönnelid, Daniel L. Mueller, Mikael C. I. Karlsson, Mariana J. Kaplan, Karl Skriner, Lars Klareskog, Fredrik Wermeling, Vivianne Malmström, Caroline Grönwall
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Frontiers Media S.A. 2019-01-01
Reeks:	Frontiers in Immunology
Onderwerpen:	anti-citrullinated protein autoantibodies acetylation rheumatoid arthritis anti-CCP PAD4 apoptosis
Online toegang:	https://www.frontiersin.org/article/10.3389/fimmu.2018.03033/full
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