HLA-DR+CD38+ activated Th17.1 cells reflect disease activity and corticosteroid responsiveness in pulmonary sarcoidosis

Abstract Background Sarcoidosis is a systemic granulomatous disease caused by sustained activation of CD4+ T cells following exposure to unknown antigens. Th17.1 cells appear to play important roles in the pathophysiology of pulmonary sarcoidosis by differentiating from Th17 cells through interactio...

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Detalhes bibliográficos

Principais autores:	Tsukie Kin Tsukuda, Minoru Fujimoto, Hiroshi Ohnishi, Kousuke Ooyama, Yu Nakatani, Takehiko Ito, Junki Terada, Yuichi Baba, Toru Kubo, Akihito Yokoyama, Tetsuji Naka, Toshiyuki Kozuki
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-06-01
Colecção:	Respiratory Research
Assuntos:	Pulmonary sarcoidosis Th17.1 cell Activated CD4+ T cell Regulatory T cell Corticosteroid responsiveness Connective tissue disease-associated interstitial lung disease
Acesso em linha:	https://doi.org/10.1186/s12931-026-03758-4
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