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Assembly and breakage of head-to-head double hexamer reveals mpox virus E5-catalyzed DNA unwinding initiation

Abstract The replicative helicase-catalyzed unwinding of the DNA double helix is the initiation of DNA replication. Helicases and primases are functionally related enzymes that have even been expressed as fusion proteins in some organisms and viruses. However, the mechanism underlying DNA unwinding...

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Principais autores: Yingxian Cheng, Pu Han, Qi Peng, Ruili Liu, Hao Liu, Bin Yuan, Yunfei Zhao, Lu Kuai, Jianxun Qi, Kai Miao, Yi Shi, George Fu Gao, Han Wang
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2025-06-01
Series:Nature Communications
Acceso en liña:https://doi.org/10.1038/s41467-025-60539-1
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