Drp1 SUMO/deSUMOylation by Senp5 isoforms influences ER tubulation and mitochondrial dynamics to regulate brain development

Summary: Brain development is a highly orchestrated process requiring spatiotemporally regulated mitochondrial dynamics. Drp1, a key molecule in the mitochondrial fission machinery, undergoes various post-translational modifications including conjugation to the small ubiquitin-like modifier (SUMO)....

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Bibliographic Details

Main Authors:	Seiya Yamada, Ayaka Sato, Naotada Ishihara, Hiroki Akiyama, Shin-ichi Sakakibara
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2021-12-01
Series:	iScience
Subjects:	Cellular neuroscience Molecular neuroscience Molecular physiology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004221014553
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