Use of Poly(vinyl alcohol) in Spray-Dried Dispersions: Enhancing Solubility and Stability of Proteolysis Targeting Chimeras

PROTACs, proteolysis targeting chimeras, are bifunctional molecules inducing protein degradation through a unique proximity-based mode of action. While offering several advantages unachievable by classical drugs, PROTACs have unfavorable physicochemical properties that pose challenges in application...

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Autores principales:	Lena Mareczek, Lena K. Mueller, Laura Halstenberg, Thomas M. Geiger, Michael Walz, Min Zheng, Felix Hausch
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2024-07-01
Colección:	Pharmaceutics
Materias:	PROTACs spray drying Poly(vinyl alcohol) PVA protein degraders amorphous solid dispersion
Acceso en línea:	https://www.mdpi.com/1999-4923/16/7/924
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