An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies
Abstract The human α7 nicotinic receptor is a pentameric channel mediating cellular and neuronal communication. It has attracted considerable interest in designing ligands for the treatment of neurological and psychiatric disorders. To develop a novel class of α7 ligands, we recently generated two n...
محفوظ في:
| المؤلفون الرئيسيون: | , , , , , , , , , , , |
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| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
Nature Portfolio
2023-09-01
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| سلاسل: | Nature Communications |
| الوصول للمادة أونلاين: | https://doi.org/10.1038/s41467-023-41734-4 |
| الوسوم: |
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