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Inhibition of IP3R/Ca2+ Dysregulation Protects Mice From Ventilator-Induced Lung Injury via Endoplasmic Reticulum and Mitochondrial Pathways

RationaleDisruption of intracellular calcium (Ca2+) homeostasis is implicated in inflammatory responses. Here we investigated endoplasmic reticulum (ER) Ca2+ efflux through the Inositol 1,4,5-trisphosphate receptor (IP3R) as a potential mechanism of inflammatory pathophysiology in a ventilator-induc...

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Principais autores: Liu Ye, Qi Zeng, Maoyao Ling, Riliang Ma, Haishao Chen, Fei Lin, Zhao Li, Linghui Pan
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-09-01
Serier:Frontiers in Immunology
Fag:
ventilator-induced lung injury
calcium
inositol 1,4,5-trisphosphate receptor
endoplasmic reticulum stress
mitochondrial dysfunction
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2021.729094/full
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