Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult

Objective: Mitochondrial pyruvate is a critical intermediary metabolite in gluconeogenesis, lipogenesis, and NADH production. As a result, the mitochondrial pyruvate carrier (MPC) complex has emerged as a promising therapeutic target in metabolic diseases. Clinical trials are currently underway. How...

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Principais autores:	Nicole K.H. Yiew, Joel H. Vazquez, Michael R. Martino, Stefanie Kennon-McGill, Jake R. Price, Felicia D. Allard, Eric U. Yee, Alexander J. Layman, Laura P. James, Kyle S. McCommis, Brian N. Finck, Mitchell R. McGill
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2023-11-01
Series:	Molecular Metabolism
Assuntos:	Acetaminophen Diabetes Glutathione Liver Metabolism Oxidative stress
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2212877823001424
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