Human N-Acetyltransferase 1 and 2 Differ in Affinity Towards Acetyl-Coenzyme A Cofactor and N-Hydroxy-Arylamine Carcinogens

Arylamine N-acetyltransferases catalyze the transfer of acetyl groups from the endogenous cofactor acetyl coenzyme A (AcCoA) to arylamine (N-acetylation) and N-hydroxy-arylamine (O-acetylation) acceptors. Humans express two arylamine N-acetyltransferase isozymes (NAT1 and NAT2) which catalyze both N...

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Κύριοι συγγραφείς:	David W. Hein, Mark A. Doll, Mariam R. Habil
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2022-02-01
Σειρά:	Frontiers in Pharmacology
Θέματα:	acetyl coenzyme A arylamine N-acetyltransferase 1 arylamine N-acetyltransferase 2 N-acetylation O-acetylation affinity
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fphar.2022.821133/full
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