Novel Repurposing of Empagliflozin-Loaded Buccal Composite (Chitosan/Silk Fibroin/Poly(lactic acid)) Nanofibers for Alzheimer’s Disease Management via Modulation of Aβ–AGER–p-tau Pathway

<b>Background/Objectives</b>: Empagliflozin (EMPA) was repurposed for Alzheimer’s disease (AD) treatment via buccal delivery, exploiting novel nanofibers (NFs) integrating chitosan (Cs), silk fibroin (Fb), and poly(lactic acid) (PLA). <b>Methods</b>: EMPA-loaded Cs/Fb/PLA NFs were electrospun in dif...

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Principais autores:	Walaa A. El-Dakroury, Samar A. Salim, Abdelrahman R. Said, Gihan F. Asaad, Mohamed F. Abdelhameed, Marwa E. Shabana, Mohamed M. Ibrahim, Sara G. Abualmajd, Haidy H. Mosaad, Aliaa A. Salama, Shrouk E. Asran, Mayar L. Amer, Ahmed S. Doghish, Fatma Sa’eed El-Tokhy
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-01-01
coleção:	Pharmaceutics
Assuntos:	Alzheimer’s disease empagliflozin fibroin chitosan polylactic acid nanofibers
Acesso em linha:	https://www.mdpi.com/1999-4923/18/1/83
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