Off-target interactions in the CRISPR-Cas9 Machinery: mechanisms and outcomes

The in vivo editing of genetic information necessitates tools of unprecedented accuracy. CRISPR-Cas-based systems have emerged as leading technologies for precisely targeting the genome. The Cas9 endonuclease derived from Streptococcus pyogenes is the most commonly used instrument for targeted DNA c...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Lyubov Yu. Kanazhevskaya, Polina V. Zhdanova, Alexander A. Chernonosov, Vladimir V. Koval
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2025-09-01
סדרה:	Biochemistry and Biophysics Reports
נושאים:	CRISPR Cas9 Genome editing sgRNA Mismatch tolerance Off-target activity
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S2405580825002213
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!