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c-di-AMP accumulation impairs toxin expression of Bacillus anthracis by down-regulating potassium importers

ABSTRACT The Gram-positive bacterium Bacillus anthracis is the causative agent of anthrax and a bioterrorism threat worldwide. As a crucial second messenger in many bacterial species, cyclic di-AMP (c-di-AMP) modulates various key processes for bacterial homeostasis and pathogenesis. Overaccumulatio...

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Main Authors: Jia Hu, Junmin Yao, Chengfeng Lei, Xiulian Sun
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2024-08-01
Series:Microbiology Spectrum
Subjects:
potassium importer
c-di-AMP receptors
anthrax toxin
KtrC
KdpD
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03786-23
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