The renoprotective efficacy and safety of genetically-engineered human bone marrow-derived mesenchymal stromal cells expressing anti-fibrotic cargo

Abstract Background Kidney fibrosis is a hallmark of chronic kidney disease (CKD) and compromises the viability of transplanted human bone marrow-derived mesenchymal stromal cells (BM-MSCs). Hence, BM-MSCs were genetically-engineered to express the anti-fibrotic and renoprotective hormone, human rel...

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Autors principals:	Yifang Li, Alex Hunter, Miqdad M. Wakeel, Guizhi Sun, Ricky W. K. Lau, Brad R. S. Broughton, Ivan E. Oyarce Pino, Zihao Deng, Tingfang Zhang, Padma Murthi, Mark P. Del Borgo, Robert E. Widdop, Jose M. Polo, Sharon D. Ricardo, Chrishan S. Samuel
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2024-10-01
Col·lecció:	Stem Cell Research & Therapy
Matèries:	Chronic kidney disease Fibrosis BM-MSCs Relaxin Genetic engineering
Accés en línia:	https://doi.org/10.1186/s13287-024-03992-x
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