Spatial extent of charge repulsion regulates assembly pathways for lysozyme amyloid fibrils.
Formation of large protein fibrils with a characteristic cross β-sheet architecture is the key indicator for a wide variety of systemic and neurodegenerative amyloid diseases. Recent experiments have strongly implicated oligomeric intermediates, transiently formed during fibril assembly, as critical...
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| Huvudupphov: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
Public Library of Science (PLoS)
2011-01-01
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| Serie: | PLoS ONE |
| Länkar: | http://europepmc.org/articles/PMC3071722?pdf=render |
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