Tumor- and host-derived heparanase-2 (Hpa2) attenuates tumorigenicity: role of Hpa2 in macrophage polarization and BRD7 nuclear localization

Abstract Little attention was given to heparanase 2 (Hpa2) over the last two decades, possibly because it lacks a heparan sulfate (HS)-degrading activity typical of heparanase. Emerging results suggest, nonetheless, that Hpa2 plays a role in human pathologies, including cancer progression where it f...

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Detalhes bibliográficos

Principais autores:	Soaad Soboh, Avital Vorontsova, Malik Farhoud, Uri Barash, Inna Naroditsky, Miriam Gross-Cohen, Marina Weissmann, Yasuhiko Nishioka, Adrian S. Woolf, Neil A. Roberts, Yuval Shaked, Neta Ilan, Israel Vlodavsky
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2024-12-01
coleção:	Cell Death and Disease
Acesso em linha:	https://doi.org/10.1038/s41419-024-07262-9
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