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Weakly acidic carboxy group-grafted β-cyclodextrin-threaded acid-degradable polyrotaxanes for modulating protein interaction and cellular internalization

To improve the therapeutic potential of β-cyclodextrin (β-CD)-threaded acid-degradable polyrotaxanes (β-CD PRXs) in cholesterol-related metabolic disorders, we investigated the effect of carboxylation of β-CD PRXs on intracellular uptake. In this study, we established a synthetic method for the modi...

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Principais autores: Shunyao Zhang, Atsushi Tamura, Nobuhiko Yui
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2021-12-01
Serier:Science and Technology of Advanced Materials
Fag:
polyrotaxane
β-cyclodextrin
carboxy group
protein interaction
intracellular uptake
Online adgang:http://dx.doi.org/10.1080/14686996.2021.1935315
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