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Evaluating the Antihyperalgesic Potential of Sildenafil–Metformin Combination and Its Impact on Biochemical Markers in Alloxan-Induced Diabetic Neuropathy in Rats

(1) Background: Globally, about 600 million people are afflicted with diabetes, and one of its most prevalent complications is neuropathy, a debilitating condition. At the present time, the exploration of novel therapies for alleviating diabetic-neuropathy-associated pain is genuinely captivating, c...

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Main Authors: Ciprian Pușcașu, Simona Negreș, Cristina Elena Zbârcea, Anca Ungurianu, Emil Ștefănescu, Nicoleta Mirela Blebea, Cornel Chiriță
Format: Artigo
Language:Inglês
Published: MDPI AG 2024-06-01
Series:Pharmaceuticals
Subjects:
diabetic neuropathy
sildenafil
metformin
antihyperalgesic
IL-6
TNF-α
Online Access:https://www.mdpi.com/1424-8247/17/6/783
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