Nrf2 regulates iron-dependent hippocampal synapses and functional connectivity damage in depression

Abstract Neuronal iron overload contributes to synaptic damage and neuropsychiatric disorders. However, the molecular mechanisms underlying iron deposition in depression remain largely unexplored. Our study aims to investigate how nuclear factor-erythroid 2 (NF-E2)-related factor 2 (Nrf2) ameliorate...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Ting Zeng, Junjie Li, Lingpeng Xie, Zhaoyang Dong, Qing Chen, Sha Huang, Shuwen Xie, Yuqi Lai, Jun Li, Weixin Yan, YuHua Wang, Zeping Xie, Changlei Hu, Jiayi Zhang, Shanshan Kuang, Yuhong Song, Lei Gao, Zhiping Lv
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-09-01
coleção:	Journal of Neuroinflammation
Assuntos:	Depression Iron metabolism Nrf2 Synapse damage Rs-fMR
Acesso em linha:	https://doi.org/10.1186/s12974-023-02875-x
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!