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Human papillomavirus disease in GATA2 deficiency: a genetic predisposition to HPV-associated female anogenital malignancy

ObjectivePatients with pathogenic variants in the GATA Binding Protein 2 (GATA2), a hematopoietic transcription factor, are at risk for human papillomavirus-related (HPV) anogenital cancer at younger than expected ages. A female cohort with GATA2 haploinsufficiency was systematically assessed by two...

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Autori principali: Ehren Dancy, Pamela Stratton, Dominique C. Pichard, Beatriz E. Marciano, Edward W. Cowen, Alison A. McBride, Koenraad Van Doorslaer, Melissa A. Merideth, Noemi Salmeri, Marybeth S. Hughes, Theo Heller, Mark Parta, Dennis D. Hickstein, Heidi H. Kong, Steven M. Holland, Christa S. Zerbe
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2024-08-01
Serie:Frontiers in Immunology
Soggetti:
GATA2 haploinsufficiency
human papillomavirus
HPV
high-grade squamous epithelial lesion
HSIL
hematopoietic stem cell transplantation
Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1445711/full
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