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Novel Natural Inhibitors Targeting Enhancer of Zeste Homolog 2: A Comprehensive Structural Biology Research

The enhancer of zeste homolog 2 (EZH2) is a methylated modification enzyme of Histone H3-Lys 27. The high expression of EZH2 in cells is closely related to the progression, invasion, and metastasis of neoplasm. Therefore, this target is gradually becoming one of the research hot spots of tumor patho...

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Principais autores: Weihang Li, Ziyi Ding, Yunlong Zhao, Min Jiang, Shilei Zhang, Hongzhe Zhao, Ke Lei, Rui Xu, Yingjing Zhao, Dong Wang, Min Chao, Yanjiang Yin, Changbin Yang, Liang Wang, Ming Yan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-10-01
coleção:Frontiers in Oncology
Assuntos:
EZH2
inhibitor
histone methyltransferase
structural biology
virtual screening
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2021.741403/full
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