Association of mitochondrial DNA copy number with cardiometabolic diseases

Summary: Mitochondrial DNA (mtDNA) is present in multiple copies in human cells. We evaluated cross-sectional associations of whole-blood mtDNA copy number (CN) with several cardiometabolic disease traits in 408,361 participants of multiple ancestries in TOPMed and UK Biobank. Age showed a threshold...

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المؤلفون الرئيسيون:	Xue Liu, Ryan J. Longchamps, Kerri L. Wiggins, Laura M. Raffield, Lawrence F. Bielak, Wei Zhao, Achilleas Pitsillides, Thomas W. Blackwell, Jie Yao, Xiuqing Guo, Nuzulul Kurniansyah, Bharat Thyagarajan, Nathan Pankratz, Stephen S. Rich, Kent D. Taylor, Patricia A. Peyser, Susan R. Heckbert, Sudha Seshadri, L. Adrienne Cupples, Eric Boerwinkle, Megan L. Grove, Nicholas B. Larson, Jennifer A. Smith, Ramachandran S. Vasan, Tamar Sofer, Annette L. Fitzpatrick, Myriam Fornage, Jun Ding, Adolfo Correa, Goncalo Abecasis, Bruce M. Psaty, James G. Wilson, Daniel Levy, Jerome I. Rotter, Joshua C. Bis, Claudia L. Satizabal, Dan E. Arking, Chunyu Liu
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Elsevier 2021-10-01
سلاسل:	Cell Genomics
الموضوعات:	mitochondrial DNA copy number cardiometabolic disease whole-genome sequencing whole-exom sequencing aging white blood cell counts
الوصول للمادة أونلاين:	http://www.sciencedirect.com/science/article/pii/S2666979X21000069
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!